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Once-weekly 2.4mg semaglutide led to a 12.7 kg (~28 lb) weight loss over placebo in the pivotal Phase 3 trial (NCT03548935)
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If people with T2DM and a BMI ≥30 kg/m 2 fail to reduce weight or improve steatotic liver, or exhibit poor blood glucose control on non-surgical treatments, bariatric surgery should be considered
